RT to a vol exposing the thyroid gland

TBI

MIBG therapy (I-131 MIBG therapy)

RT >= 10 Gy to a vol exposing the breasts

OR upper abdominal field radiation that can extend above the diaphragm likely exposing breast tissue at a young age

RT >= 35 Gy to a vol exposing the heart

Anthracyclines (doxorubicin isotoxic equivalents)>= 250 mg/m2

RT >= 15 Gy to a vol exposing the heart AND Anthracyclines (doxorubicin isotoxic equivalents)>= 100 mg/m2

Alkylating agents

RT to a vol exposing the testes

RT between 15 and 35 Gy to a vol exposing the heart

RT to a vol exposing the testes or pelvis

Surgery to the spinal cord, sympathetic nerves or pelvis

Hypogonadal

RT to a vol exposing the ovaries

RT >= 30 Gy to a vol exposing the head or the brain

Cisplatin (with or without carboplatin > 1500 mg/m2)

RT to a vol exposing the pancreas

HSCT

RT to a volume exposing the hypothalamus or pituatary gland

Hypothalamic or pituitary tumour

Neurosurgery of the hypothalamus or pituitary gland

RT to a vol exposing the kidneys, heart and associated large vessels

Nephrectomy

Ifosfamide

Platinium based chemotherapy

Nitrosureas

Immunosuppressives treatment and prolonged steroids as anticancer treatment (at least 4 weeks, continuously)

Cranial and/or spinal RT

Methotrexate

Gonadal failure

Growth hormone deficiency

Prolonged (at least 4 weeks, continuously) corticosteroids as anti-cancer treatment

High dose RT

Radiotherapy to a vol exposing the HP region >= 30 Gy

Surgery near or within the HP region

CNS tumours near or within the HP region

Radiotherapy to a vol exposing the HP region< 30 Gy

Hydrocephalus or cerebrospinal fluid shunt (Risk factor for GHD)

Radiotherapy to a vol exposing the HP region

Surgery near or within the HP region

Radiotherapy to a vol exposing the HP region

Surgery near or within the HP region

RT to a vol exposing the thyroid gland

Radioiodine therapy (I-131 ablation therapy)

Allogenic HSCT

Total thyroidectomy

RT to a vol exposing the head, brain or neck

History of a central nervous system tumor

RT to a vol exposing the brain ANY DOSE

Brain surgery

High dose cytarabine IV (intravenous)

High dose MTX IV

Any Chemotherapy IT (intrathecal)

Vinca-Alkaloids

Cisplatin or carboplatin

RT to a vol exposing the lens

RT to a vol exposing the eye and orbit

Radioiodine therapy (I-131 ablation therapy)

RT to a vol exposing the craniofacial area, especially after high doses and at a young age

Surgery to the face, especially at a young age

Surgery of the spine

Surgery of the chest (Does not include CVC pose)

RT to a vol exposing the spine

Spinal or paraspinal malignancies

Cyclophosphamide

RT to a vol exposing the bladder

Cystectomy

Hysterectomy

Pelvic surgery

Spinal cord surgery

RT to a vol exposing the uterus only female

RT to a vol exposing the oral cavity or salivary glands

Chemotherapy

RT to a vol exposing the gastro-intestinal tract

Oesophageal surgery

Abdominal surgery

With a history of chronic GVHD

Anthracyclines (doxorubicin isotoxic equivalents) <100 mg/m2

RT to a vol exposing the lungs

Bleomycin

Busulfan

BCNU Carmustine

CCNU Lomustine

Thoracic surgery

Cisplatin Any dose

Carboplatin Any dose

RT to a volume exposing the liver

HSCT (irrespective of GVHD)

Mercaptopurine Thioguanine

Dactinomycin

Chronic viral hepatitis

Sinusoidal obstruction syndrome

Chronic GVHD

Liver surgery

Multiple red blood cell transfusions

Splenectomy

RT >= 10 Gy to a vol exposing the spleen

Autologus HSCT conditioned with TBI

Hereditary cancer sd

Any RT including TBI

RT to a vol exposing the colon and rectum

RT to a vol exposing the oral cavity

Anthracyclines and/or Mitoxantrone

Epipodophyllotoxins or autologous

Autologous haematopoietic stem cell transplant

Ciclofosfamide, Ifosfamide (particularly if they have a history of severe hemorrhagic cystitis)

RT to a vol exposing the bladder

RT to a vol exposing the lungs

RT to a vol exposing the head or brain

Anthracyclines (doxorubicin isotoxic equivalents) between 100 and 250 mg/m2

RT to a vol exposing the kidney or urinary tract