HL7 Europe Laboratory Report
2.0.0 - ci-build 150

HL7 Europe Laboratory Report - Downloaded Version 2.0.0 See the Directory of published versions

## Resource Profile: Substance: Specimen Additive Substance

Official URL: http://hl7.eu/fhir/laboratory/StructureDefinition/Substance-additive-eu-lab | Version: 2.0.0
Active as of 2026-05-05 | Computable Name: SpecimenAdditiveSubstance
Copyright/Legal: Copyright HL7 Europe. Licensed under creative commons public domain (CC0 1.0).

This profile defines how to represent Specimen Additive Substances in HL7 FHIR for the purpose of this guide.

Usages:

- Refer to this Profile: Specimen: Laboratory

You can also check for usages in the FHIR IG Statistics

### Formal Views of Profile Content

Description of Profiles, Differentials, Snapshots and how the different presentations work.

- Key Elements Table
- Differential Table
- Snapshot Table
- Statistics/References
- All

Name | Flags | Card. | Type | Description & Constraints Filter: Bindings Constraints Obligations
--- | --- | --- | --- | ---
Substance |  | 0..* | Substance | A homogeneous material with a definite composition
implicitRules | ?!Σ | 0..1 | uri | A set of rules under which this content was created
modifierExtension | ?! | 0..* | Extension | Extensions that cannot be ignored
status | ?!Σ | 0..1 | code | active | inactive | entered-in-error Binding: FHIRSubstanceStatus (required): A code to indicate if the substance is actively used.
code | Σ | 1..1 | CodeableConcept | What substance this is Binding: Specimen Additive (preferred)
Documentation for this format

#### Terminology Bindings

Path | Status | Usage | ValueSet | Version | Source
Substance.status | Base | required | FHIRSubstanceStatus | 📍4.0.1 | FHIR Std.
Substance.code | Base | preferred | Specimen Additive | 📦2.0.0 | This IG

#### Constraints

Id | Grade | Path(s) | Description | Expression
dom-2 | error | Substance | If the resource is contained in another resource, it SHALL NOT contain nested Resources | `contained.contained.empty()`
dom-3 | error | Substance | If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource | `contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()`
dom-4 | error | Substance | If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated | `contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()`
dom-5 | error | Substance | If a resource is contained in another resource, it SHALL NOT have a security label | `contained.meta.security.empty()`
dom-6 | best practice | Substance | A resource should have narrative for robust management | `text.`div`.exists()`
ele-1 | error | **ALL** elements | All FHIR elements must have a @value or children | `hasValue() or (children().count() > id.count())`
ext-1 | error | **ALL** extensions | Must have either extensions or value[x], not both | `extension.exists() != value.exists()`

This structure is derived from Substance

Name | Flags | Card. | Type | Description & Constraints Filter: Bindings Constraints Obligations
--- | --- | --- | --- | ---
Substance |  | 0..* | Substance | A homogeneous material with a definite composition
code |  | 1..1 | CodeableConcept | What substance this is Binding: Specimen Additive (preferred)
Documentation for this format

#### Terminology Bindings (Differential)

Path | Status | Usage | ValueSet | Version | Source
Substance.code | Base | preferred | Specimen Additive | 📦2.0.0 | This IG

Name | Flags | Card. | Type | Description & Constraints Filter: Bindings Constraints Obligations
--- | --- | --- | --- | ---
Substance |  | 0..* | Substance | A homogeneous material with a definite composition
id | Σ | 0..1 | id | Logical id of this artifact
meta | Σ | 0..1 | Meta | Metadata about the resource
implicitRules | ?!Σ | 0..1 | uri | A set of rules under which this content was created
language |  | 0..1 | code | Language of the resource content Binding: CommonLanguages (preferred): A human language.
Additional Bindings | Purpose
AllLanguages | Max Binding
text |  | 0..1 | Narrative | Text summary of the resource, for human interpretation This profile does not constrain the narrative in regard to content, language, or traceability to data elements
contained |  | 0..* | Resource | Contained, inline Resources
extension |  | 0..* | Extension | Additional content defined by implementations
modifierExtension | ?! | 0..* | Extension | Extensions that cannot be ignored
identifier | Σ | 0..* | Identifier | Unique identifier
status | ?!Σ | 0..1 | code | active | inactive | entered-in-error Binding: FHIRSubstanceStatus (required): A code to indicate if the substance is actively used.
category | Σ | 0..* | CodeableConcept | What class/type of substance this is Binding: SubstanceCategoryCodes (extensible): Category or classification of substance.
code | Σ | 1..1 | CodeableConcept | What substance this is Binding: Specimen Additive (preferred)
description | Σ | 0..1 | string | Textual description of the substance, comments
instance | Σ | 0..* | BackboneElement | If this describes a specific package/container of the substance
id |  | 0..1 | string | Unique id for inter-element referencing
extension |  | 0..* | Extension | Additional content defined by implementations
modifierExtension | ?!Σ | 0..* | Extension | Extensions that cannot be ignored even if unrecognized
identifier | Σ | 0..1 | Identifier | Identifier of the package/container
expiry | Σ | 0..1 | dateTime | When no longer valid to use
quantity | Σ | 0..1 | SimpleQuantity(4.0.1) | Amount of substance in the package
ingredient | Σ | 0..* | BackboneElement | Composition information about the substance
id |  | 0..1 | string | Unique id for inter-element referencing
extension |  | 0..* | Extension | Additional content defined by implementations
modifierExtension | ?!Σ | 0..* | Extension | Extensions that cannot be ignored even if unrecognized
quantity | Σ | 0..1 | Ratio | Optional amount (concentration)
substance[x] | Σ | 1..1 |  | A component of the substance Binding: SubstanceCode (example): Substance Ingredient codes.
substanceCodeableConcept |  |  | CodeableConcept |
substanceReference |  |  | Reference(Substance) |
Documentation for this format

#### Terminology Bindings

Path | Status | Usage | ValueSet | Version | Source
Substance.language | Base | preferred | Common Languages | 📍4.0.1 | FHIR Std.
Substance.status | Base | required | FHIRSubstanceStatus | 📍4.0.1 | FHIR Std.
Substance.category | Base | extensible | Substance Category Codes | 📍4.0.1 | FHIR Std.
Substance.code | Base | preferred | Specimen Additive | 📦2.0.0 | This IG
Substance.ingredient.​substance[x] | Base | example | Substance Code | 📍4.0.1 | FHIR Std.

#### Constraints

Id | Grade | Path(s) | Description | Expression
dom-2 | error | Substance | If the resource is contained in another resource, it SHALL NOT contain nested Resources | `contained.contained.empty()`
dom-3 | error | Substance | If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource | `contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()`
dom-4 | error | Substance | If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated | `contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()`
dom-5 | error | Substance | If a resource is contained in another resource, it SHALL NOT have a security label | `contained.meta.security.empty()`
dom-6 | best practice | Substance | A resource should have narrative for robust management | `text.`div`.exists()`
ele-1 | error | **ALL** elements | All FHIR elements must have a @value or children | `hasValue() or (children().count() > id.count())`
ext-1 | error | **ALL** extensions | Must have either extensions or value[x], not both | `extension.exists() != value.exists()`

This structure is derived from Substance

Summary

Key Elements View

Name | Flags | Card. | Type | Description & Constraints Filter: Bindings Constraints Obligations
--- | --- | --- | --- | ---
Substance |  | 0..* | Substance | A homogeneous material with a definite composition
implicitRules | ?!Σ | 0..1 | uri | A set of rules under which this content was created
modifierExtension | ?! | 0..* | Extension | Extensions that cannot be ignored
status | ?!Σ | 0..1 | code | active | inactive | entered-in-error Binding: FHIRSubstanceStatus (required): A code to indicate if the substance is actively used.
code | Σ | 1..1 | CodeableConcept | What substance this is Binding: Specimen Additive (preferred)
Documentation for this format

#### Terminology Bindings

Path | Status | Usage | ValueSet | Version | Source
Substance.status | Base | required | FHIRSubstanceStatus | 📍4.0.1 | FHIR Std.
Substance.code | Base | preferred | Specimen Additive | 📦2.0.0 | This IG

#### Constraints

Id | Grade | Path(s) | Description | Expression
dom-2 | error | Substance | If the resource is contained in another resource, it SHALL NOT contain nested Resources | `contained.contained.empty()`
dom-3 | error | Substance | If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource | `contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()`
dom-4 | error | Substance | If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated | `contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()`
dom-5 | error | Substance | If a resource is contained in another resource, it SHALL NOT have a security label | `contained.meta.security.empty()`
dom-6 | best practice | Substance | A resource should have narrative for robust management | `text.`div`.exists()`
ele-1 | error | **ALL** elements | All FHIR elements must have a @value or children | `hasValue() or (children().count() > id.count())`
ext-1 | error | **ALL** extensions | Must have either extensions or value[x], not both | `extension.exists() != value.exists()`

Differential View

This structure is derived from Substance

Name | Flags | Card. | Type | Description & Constraints Filter: Bindings Constraints Obligations
--- | --- | --- | --- | ---
Substance |  | 0..* | Substance | A homogeneous material with a definite composition
code |  | 1..1 | CodeableConcept | What substance this is Binding: Specimen Additive (preferred)
Documentation for this format

#### Terminology Bindings (Differential)

Path | Status | Usage | ValueSet | Version | Source
Substance.code | Base | preferred | Specimen Additive | 📦2.0.0 | This IG

Snapshot View

Name | Flags | Card. | Type | Description & Constraints Filter: Bindings Constraints Obligations
--- | --- | --- | --- | ---
Substance |  | 0..* | Substance | A homogeneous material with a definite composition
id | Σ | 0..1 | id | Logical id of this artifact
meta | Σ | 0..1 | Meta | Metadata about the resource
implicitRules | ?!Σ | 0..1 | uri | A set of rules under which this content was created
language |  | 0..1 | code | Language of the resource content Binding: CommonLanguages (preferred): A human language.
Additional Bindings | Purpose
AllLanguages | Max Binding
text |  | 0..1 | Narrative | Text summary of the resource, for human interpretation This profile does not constrain the narrative in regard to content, language, or traceability to data elements
contained |  | 0..* | Resource | Contained, inline Resources
extension |  | 0..* | Extension | Additional content defined by implementations
modifierExtension | ?! | 0..* | Extension | Extensions that cannot be ignored
identifier | Σ | 0..* | Identifier | Unique identifier
status | ?!Σ | 0..1 | code | active | inactive | entered-in-error Binding: FHIRSubstanceStatus (required): A code to indicate if the substance is actively used.
category | Σ | 0..* | CodeableConcept | What class/type of substance this is Binding: SubstanceCategoryCodes (extensible): Category or classification of substance.
code | Σ | 1..1 | CodeableConcept | What substance this is Binding: Specimen Additive (preferred)
description | Σ | 0..1 | string | Textual description of the substance, comments
instance | Σ | 0..* | BackboneElement | If this describes a specific package/container of the substance
id |  | 0..1 | string | Unique id for inter-element referencing
extension |  | 0..* | Extension | Additional content defined by implementations
modifierExtension | ?!Σ | 0..* | Extension | Extensions that cannot be ignored even if unrecognized
identifier | Σ | 0..1 | Identifier | Identifier of the package/container
expiry | Σ | 0..1 | dateTime | When no longer valid to use
quantity | Σ | 0..1 | SimpleQuantity(4.0.1) | Amount of substance in the package
ingredient | Σ | 0..* | BackboneElement | Composition information about the substance
id |  | 0..1 | string | Unique id for inter-element referencing
extension |  | 0..* | Extension | Additional content defined by implementations
modifierExtension | ?!Σ | 0..* | Extension | Extensions that cannot be ignored even if unrecognized
quantity | Σ | 0..1 | Ratio | Optional amount (concentration)
substance[x] | Σ | 1..1 |  | A component of the substance Binding: SubstanceCode (example): Substance Ingredient codes.
substanceCodeableConcept |  |  | CodeableConcept |
substanceReference |  |  | Reference(Substance) |
Documentation for this format

#### Terminology Bindings

Path | Status | Usage | ValueSet | Version | Source
Substance.language | Base | preferred | Common Languages | 📍4.0.1 | FHIR Std.
Substance.status | Base | required | FHIRSubstanceStatus | 📍4.0.1 | FHIR Std.
Substance.category | Base | extensible | Substance Category Codes | 📍4.0.1 | FHIR Std.
Substance.code | Base | preferred | Specimen Additive | 📦2.0.0 | This IG
Substance.ingredient.​substance[x] | Base | example | Substance Code | 📍4.0.1 | FHIR Std.

#### Constraints

Id | Grade | Path(s) | Description | Expression
dom-2 | error | Substance | If the resource is contained in another resource, it SHALL NOT contain nested Resources | `contained.contained.empty()`
dom-3 | error | Substance | If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource | `contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()`
dom-4 | error | Substance | If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated | `contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()`
dom-5 | error | Substance | If a resource is contained in another resource, it SHALL NOT have a security label | `contained.meta.security.empty()`
dom-6 | best practice | Substance | A resource should have narrative for robust management | `text.`div`.exists()`
ele-1 | error | **ALL** elements | All FHIR elements must have a @value or children | `hasValue() or (children().count() > id.count())`
ext-1 | error | **ALL** extensions | Must have either extensions or value[x], not both | `extension.exists() != value.exists()`

This structure is derived from Substance

Summary

Other representations of profile: CSV, Excel, Schematron